On the role of regulatory T cells and microbial products in the control of T and B cell immune responses
نویسندگان
چکیده
4 cell receptor (BCR) triggering and T cell help induced initial B cell proliferation but were not sufficient to sustain prolonged survival and accumulation of B cells. Extensive proliferation, isotypic switch and differentiation to Ig-secreting cells were promoted by microbial agents acting on TLRs expressed by naïve B cells upon BCR stimulation. This finding demonstrates that humoral immune responses (as cellular immune responses) are critically dependent on context discrimination via detection of PAMPs.
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